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3M™ Emphaze™ AEX Series Hybrid Purifier

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3M™ Emphaze™ AEX Series Hybrid Purifier

Over het product

3M™ Emphaze AEX Hybrid Purifier is our single-use sterilisable and sanitisable. The all-synthetic purification media that contains a Q-functional anion exchange media and a fine particle and bioburden reduction membrane.

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Productdetails

Remove impurities in biopharmaceutical process streams such as DNA, host cell proteins (HCP) and viruses with our all-synthetic, single use 3M™ Emphaze AEX Hybrid Purifier. The composite purification media is comprised of three primary components: anion exchange nonwoven, microporous membrane, and membrane support. The anion exchange media is composed of four layers of polypropylene nonwoven with a covalently attached quaternary ammonium functional polymer. The bioburden reduction membrane is a highly asymmetric polyamide membrane which has nine zones of decreasing pore size, spanning approximately a 20 X range, and terminating with a 0.2 μm rated qualifying layer. This is followed by a polypropylene nonwoven used as a support layer in the capsule. Capsules There are two primary capsule configurations for the Emphaze AEX Hybrid Purifier, Laboratory and Scale-up capsules: - The Laboratory capsule (BV8) has an 8ml bed volume - The Scale-up capsules are constructed from a lenticular media cell design having bed volumes of 120 mls and 360 mls (BV 120 and BV 360 respectively) - The Production capsules are scaled to meet your manufacturing requirements and utilise manifolds in a holder for ease of use A full support package is available for 3M Emphaze AEX Hybrid Purifiers. This package includes Installation and Operation Guides, a Certificate of Quality and a Regulatory Support File.
  • Reduces turbidity, HCP, DNA and bioburden.
  • Excellent throughput and mAb recovery.
  • Enhanced capture column performance and protection.
  • Substantial turbidity, DNA, HCP and bioburden reduction.
  • Reduced surface area requirement of the downstream sterilizing grade membrane.
  • May offer differentiated protection of the protein A column for enhanced contaminant clearance performance.
  • All product components comply with United States Pharmacopeia (USP) Class VI 70°C Biological Reactivity Tests, in vivo.

Voorgestelde toepassingen

  • Use for the clarification of mammalian cell cultures and to optimise downstream processes for monoclonal antibodies (mAbs)

Productspecificaties

Eindaanpassing
Eindaanpassing

3/4 in Sanitary Connectors, Luer Loc, 1 1/2 in Sanitary Connectors

Categorienaam
Categorienaam

Chromatografiefilters

Totale hoogte (imperiaal)
Totale hoogte (imperiaal)

4.06 in, 2.32 in, 7.99 in, 5.98 in, 2.24 in, 1.89 in, 1.77 in, 3.46 in

Toepassing
Toepassing

Oogsten en klaring

Micronage
Micronage

0.2 μm

Totale hoogte (metrisch)
Totale hoogte (metrisch)

10.3 cm, 5.9 cm, 20.3 cm, 15.2 cm, 5.7 cm, 4.8 cm, 4.5 cm, 8.8 cm

Totale diameter (metrisch)
Totale diameter (metrisch)

21.6 cm, 4.3 cm, 45.2 cm, 7.7 cm

Debiet (metrisch)
Debiet (metrisch)

100 ml/min, 1.4 ml/min, 4700 ml/min, 50 ml/min, 300 ml/min, 680 ml/min, 0.4 ml/min, 8 ml/min

Debiet
Debiet

0.022 gal/min, 0 gal/min, 1.034 gal/min, 0.011 gal/min, 0.066 gal/min, 0.15 gal/min, 0.002 gal/min

Sectoren
Sectoren

Biofarmaceutische productie

Merk
Merk

Emphaze™

Totale diameter (Brits)
Totale diameter (Brits)

8.5 in, 1.69 in, 17.8 in, 3.03 in

Productserie
Productserie

AEX

Filtertype
Filtertype

Eenmalig gebruik

Filtertechnologie
Filtertechnologie

Anion exchange-chromatografie

Nettogewicht (metrisch)
Nettogewicht (metrisch)

1.1 kg, 14.5 g, 9.5 kg, 1.6 kg, 3.4 kg, 9 g, 71 g, 77 g

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